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Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes

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dc.contributor.author TÜRKEZ, Hasan
dc.date.accessioned 2015-01-07T14:28:31Z
dc.date.available 2015-01-07T14:28:31Z
dc.date.issued 2011
dc.identifier.uri http://openaccess.erzurum.edu.tr/xmlui/handle/123456789/32
dc.description.abstract The aim of this study was to investigate the protective effects of olive leaf extract (OLE) on genotoxicity and oxidative damage in cultured human blood cells treated with permethrin (PM) in the presence of a rat liver S9 mix containing cytochrome P 450 enzymes. Anti-genotoxic activities of OLE were studied using sister chromatid exchange (SCE) and chromosome aberration (CA) tests and furthermore total antioxidant capacity (TAC) and total oxidative status (TOS) were examined to determine the oxidative damage. Our results clearly revealed that treatment with PM (200 mg/l) alone increased SCE and CA rates and TOS level, decreased TAC level in cultured human blood cells. The OLE alone at the all tested doses did not induce any significant changes in the genotoxicity endpoint. However OLE leads to increases of plasma TAC level in vitro. OLE starts showing this positive effect at 100 mg/l. The combined treatment showed significant improvements in cytogenetic and biochemical parameters tested. Moreover, this improvement was more pronounced in the group received the high dose of the OLE. It could be concluded that the ethanol extract of OLE induced its genoprotective effect via the increase in the antioxidant capacity, inhibition of oxidative stress and scavenging of free radicals. tr_TR
dc.language.iso en tr_TR
dc.publisher The Journal of Toxicological Sciences tr_TR
dc.subject Antioxidant capacity tr_TR
dc.subject Genoprotective effect tr_TR
dc.subject Genotoxicity tr_TR
dc.subject Oxidative damage tr_TR
dc.subject Whole blood culture tr_TR
dc.title Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes tr_TR
dc.type Article tr_TR


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