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New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels

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dc.contributor.author TÜRKEZ, Hasan
dc.date.accessioned 2015-01-07T14:28:26Z
dc.date.available 2015-01-07T14:28:26Z
dc.date.issued 2013
dc.identifier.issn 1420-3049
dc.identifier.uri http://openaccess.erzurum.edu.tr/xmlui/handle/123456789/31
dc.description.abstract Alzheimer’s disease (AD) is characterized by irreversible and progressive loss of memory and cognition and profound neuronal loss. Current therapeutic strategies for the treatment of AD have been directed to a variety of targets with the aim of reversing or preventing the disease but, unfortunately, the available treatments often produce no significant clinical benefits. During the last decades compounds that inhibit or modulate γ-secretase, reducing β amyloid (Aβ) levels, have been considered as potential therapeutics or AD. Among these the (R)-enantiomer of flurbiprofen (FLU) seems to be very promising, but it shows low brain penetration. In this study, in order to improve the properties of FLU against Alzheimer’s pathogenesis we synthesized some novel FLU lipophilic analogues. Lipophilicity of the new molecules has been characterized in terms of öclogP, log KC18/W and log K IAM/W values. Permeability has been determined in both gastrointestinal PAMPA (PAMPA-GI) at different pH values and in brain blood barrier tr_TR
dc.language.iso en tr_TR
dc.publisher www.mdpi.com/jurnal/molecules tr_TR
dc.subject Alzheimer’s disease tr_TR
dc.subject beta amyloid peptide tr_TR
dc.subject flurbiprofen; γ-secretase tr_TR
dc.title New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels tr_TR
dc.type Article tr_TR


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