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Anticancer and antioxidant properties of terpinolene im rat brain cells

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dc.contributor.author TURKEZ, Hasan
dc.date.accessioned 2014-12-18T11:11:05Z
dc.date.available 2014-12-18T11:11:05Z
dc.date.issued 2013-02
dc.identifier.uri http://openaccess.erzurum.edu.tr/xmlui/handle/123456789/28
dc.description.abstract Terpinolene (TPO) is a natural monoterpene present in essential oils of many aromatic plant species. Although various biological activities of TPO have been demonstrated, its neurotoxicity has never been explored. In this in vitro study we investigated TPO’s antiproliferative and/or cytotoxic properties using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) test, genotoxic damage potential using the single-cell gel electrophoresis (SCGE), and oxidative effects through total antioxidant capacity (TAC) and total oxidative stress (TOS) in cultured primary rat neurons and N2a neuroblastoma cells. Dose-dependent effects of TPO (at 10 mg L-1, 25 mg L-1, 50 mg L-1, 100 mg L-1, 200 mg L-1, and 400 mg L-1) were tested in both cell types. Signifi cant (P<0.05) decrease in cell proliferation were observed in cultured primary rat neurons starting with the dose of 100 mg L-1 and in N2a neuroblastoma cells starting with 50 mg L-1. TPO was not genotoxic in either cell type. In addition, TPO treatment at 10 mg L-1, 25 mg L-1, and 50 mg L-1 increased TAC in primary rat neurons, but not in N2a cells. However, at concentrations above 50 mg L-1 it increased TOS in both cell types. Our fi ndings clearly demonstrate that TPO is a potent antiproliferative agent for brain tumour cells and may have potential as an anticancer agent, which needs to be further studied. tr_TR
dc.language.iso en tr_TR
dc.publisher Scientific Paper tr_TR
dc.relation.ispartofseries DOI;10.2478/10004-1254-64-2013-2365
dc.subject antiproliferative agent tr_TR
dc.subject comet assay tr_TR
dc.subject MTT assay tr_TR
dc.subject neurotoxicity tr_TR
dc.subject N2a neuroblastoma cell line tr_TR
dc.subject oxidative status tr_TR
dc.title Anticancer and antioxidant properties of terpinolene im rat brain cells tr_TR
dc.type Article tr_TR

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